INDUCTION OF P53 PROTEIN BY CARBON-ION AND PROTON-BEAM IRRADIATION IN2 CLOSE HUMAN LYMPHOBLASTOID CELL-LINES WITH DIFFERENT P53 STATUS

Authors
FUKUSHIMA S OZEKI S TANG JT KOIZUMI M MATSUMURA S INOUE T INOUE T YAMAZAKI H MURAYAMA S HATANAKA K EJIRI H KASAI K
Citation
S. Fukushima et al., INDUCTION OF P53 PROTEIN BY CARBON-ION AND PROTON-BEAM IRRADIATION IN2 CLOSE HUMAN LYMPHOBLASTOID CELL-LINES WITH DIFFERENT P53 STATUS, Oncology Reports, 4(3), 1997, pp. 481-484
Citations number
31
Categorie Soggetti
Oncology
Journal title
Oncology Reports → ACNP
ISSN journal
1021335X
Volume
4
Issue
3
Year of publication
1997
Pages
481 - 484
Database
ISI
SICI code
1021-335X(1997)4:3<481:IOPPBC>2.0.ZU;2-T
Abstract
In this study, we compared the kinetics of the postirradiation p53 pro tein expression for carbon ion beam (290 MeV/n, LET 75 keV/mu m) and p roton beam (65 MeV) with that of (13)7Cs-gamma ray. We used two human lymphoblastoid cell lines derived from the same donor with different p 53 status. Wild-type p53 protein increased after irradiation and it wa s dose-dependent. Meanwhile, the mutated p53 protein level did not sho w any increase with irradiation. With the three forms of radiation, th ere was no significant difference as regards the p53 protein kinetics.