INSULIN-LIKE-GROWTH-FACTOR (IGF)-I AND IGF-II PROTEIN EXPRESSION IN PULMONARY ADENOCARCINOMA - AN IMMUNOHISTOCHEMICAL STUDY

Authors
TAKANAMI I TANAKA F HASHIZUME T KODAIRA S
Citation
I. Takanami et al., INSULIN-LIKE-GROWTH-FACTOR (IGF)-I AND IGF-II PROTEIN EXPRESSION IN PULMONARY ADENOCARCINOMA - AN IMMUNOHISTOCHEMICAL STUDY, Oncology Reports, 4(3), 1997, pp. 493-496
Citations number
17
Categorie Soggetti
Oncology
Journal title
Oncology Reports → ACNP
ISSN journal
1021335X
Volume
4
Issue
3
Year of publication
1997
Pages
493 - 496
Database
ISI
SICI code
1021-335X(1997)4:3<493:I(AIPE>2.0.ZU;2-4
Abstract
Insulin-like growth factor (IGF)-I and IGF-II expression was studied i mmunologically in tissue specimens from 120 patients with pulmonary ad enocarcinoma and was correlated with patient prognosis. Multivariate a nalysis showed that IGF-II expression had a significant influence on p rognosis. Our findings suggest that IGF-I and IGF-II play an important role in tumor progression and that IGF-II is a useful prognostic mark er for pulmonary adenocarcinomas.