SYNTHESIS OF 4-AMINO-3-QUINOLINESULFONIC ACIDS AND 4-AMINOQUINOLINES

Authors
SKRZYPEK L
Citation
L. Skrzypek, SYNTHESIS OF 4-AMINO-3-QUINOLINESULFONIC ACIDS AND 4-AMINOQUINOLINES, Heterocycles, 48(1), 1998, pp. 71-78
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
48
Issue
1
Year of publication
1998
Pages
71 - 78
Database
ISI
SICI code
0385-5414(1998)48:1<71:SO4AA4>2.0.ZU;2-4
Abstract
The hydrolysis of 4-chloro-3-quinolinesulfonyl chloride (1) gives 4-ch loro-3-quinolinesulfonic acid (2) or 1,4-dihydro-4-oxo-3-quinolinesulf onic acid (3). Compound (2) reacts with primary and secondary aliphati c or primary aromatic amines to give 4-amino-3-quinolinesulfonic acids (4). Desulfonation of quinolinesulfonic acids (2,3,4) yields 4(1H)-qu inolinone or 4-aminoquinolines (5).