M. Yotsuyamashita et al., SYNTHESIS AND CONFIRMATION OF THE STRUCTURES OF POLONICUMTOXIN-A, POLONICUMTOXIN-B AND POLONICUMTOXIN-C, Heterocycles, 48(1), 1998, pp. 79-93
Total syntheses of polonicumtoxins A (1), B (2), and C (3) have been c
ompleted. The key step of the syntheses involves an aza-Wittig reactio
n for the construction of the cyclic ketimine. The synthetic compounds
were found to be identical in all respects with the natural products,
thus confirming their assigned structures.