SYNTHESIS AND CONFIRMATION OF THE STRUCTURES OF POLONICUMTOXIN-A, POLONICUMTOXIN-B AND POLONICUMTOXIN-C

Authors
YOTSUYAMASHITA M YASUMOTO T RAWAL VH
Citation
M. Yotsuyamashita et al., SYNTHESIS AND CONFIRMATION OF THE STRUCTURES OF POLONICUMTOXIN-A, POLONICUMTOXIN-B AND POLONICUMTOXIN-C, Heterocycles, 48(1), 1998, pp. 79-93
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
48
Issue
1
Year of publication
1998
Pages
79 - 93
Database
ISI
SICI code
0385-5414(1998)48:1<79:SACOTS>2.0.ZU;2-8
Abstract
Total syntheses of polonicumtoxins A (1), B (2), and C (3) have been c ompleted. The key step of the syntheses involves an aza-Wittig reactio n for the construction of the cyclic ketimine. The synthetic compounds were found to be identical in all respects with the natural products, thus confirming their assigned structures.