CD8 CELL NONCYTOTOXIC ANTIVIRAL ACTIVITY IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED AND - UNINFECTED CHILDREN

CD8 cells from human immunodeficiency virus (HIV)-infected adults and children can show cytotoxic as well as noncytotoxic activity against v iral replication, The noncytotoxic anti-HIV response, measured by supp ression of acute viral infection of CD4 cells, has also been observed in uninfected adults who have a history of exposure to HIV. This CD8 c ell antiviral activity was found to be detectable as well in similar t o 50% of uninfected children born of infected mothers, The findings co uld reflect a protective response of the children to HIV after being e xposed to the virus.