MYELIN SPLITTING, SCHWANN-CELL INJURY AND DEMYELINATION IN FELINE DIABETIC NEUROPATHY

Authors
MIZISIN AP SHELTON GD WAGNER S RUSBRIDGE C POWELL HC
Citation
Ap. Mizisin et al., MYELIN SPLITTING, SCHWANN-CELL INJURY AND DEMYELINATION IN FELINE DIABETIC NEUROPATHY, Acta Neuropathologica, 95(2), 1998, pp. 171-174
Citations number
23
Categorie Soggetti
Neurosciences,"Clinical Neurology",Pathology
Journal title
Acta Neuropathologica → ACNP
ISSN journal
00016322
Volume
95
Issue
2
Year of publication
1998
Pages
171 - 174
Database
ISI
SICI code
0001-6322(1998)95:2<171:MSSIAD>2.0.ZU;2-B
Abstract
Nerve biopsy samples from two cats with spontaneously occurring diabet es were examined. The predominant nerve fiber abnormalities observed w ere restricted to the myelin sheath and Schwann cell. Reactive, degene rative and proliferative Schwann cell changes were evident but the mos t striking abnormality encountered was splitting and ballooning of the myelin sheath. These observations highlight the significance of Schwa nn cell injury in the pathogenesis of diabetic neuropathy.