TROPONIN-T AS A SERUM MARKER FOR MYOCARDIAL-INFARCTION

We report here our experience with serum troponin T (TnT), measured wi th the sandwich immunoassay introduced by Boehringer Mannheim as a mar ker for myocardial infarction. We assayed TnT in serial serum samples from 30 patients with time courses of serum CK, CK-MB, AST, and LD tha t we consider typical of acute myocardial infarction (MI). In every pa tient but one, TnT rose in parallel with both CK-MB and AST, but remai ned elevated significantly longer. The ratios of the elevations of the different markers varied from patient to patient with marked variatio n in the ratio of TnT to CK-MB. There appeared to be a significant ass ociation between the magnitude of that ratio with the level of ALT. (C ) 1997 Wiley-Liss, Inc.