LYSINE-SALICYLATE BASED ANTIPYRETIC IN CL INICAL AND LABORATORY EVALUATION OF TOLERANCE IN CALVES

In clinical experiments with 26 clinically healthy calves, 2 to 4 mont hs old, Black Spotted Lowland, Slovakian Spotted cattle and their bree ds of live weight 60 to 85 kg, clinical and laboratory methods were us ed to study the effect of combined antipyretic preparation lysine-sali cylate (LS) with 20% content of salicylic acid and I-lysine (Biotika, a.s., Slovenska Lupca, SR) on the local and total tolerance, changes o f triad values (body temperature, breath and heart rates), parameters of haematological (Er - erythrocyte counts, Lc - leucocyte counts, Hb - haemoglobin concentration, Hk - haematocrit value) and acid-base blo od profile (pH, CO2, BE - base excess, SB - standard bicarbonate) and their possible changes from the side of circadian effects were compare d. Haematological examinations were performed on automatic analyzer of blood cells SERONO system 150 and blood for acid-base analysis was ex amined on the apparatus ABL 4, manufactured by Radiometer Copenhagen, Denmark. Calves divided into three groups were examined by intramuscul arily administered LS in the dose 0.5 ml per 1 kg of live weight (grou p 1, n = 11), by the same dose of physiological solution (FR, group 2, n = 9) and calves without examination (group 3, n = 6). Maximum appli ed dose of preparations per 1 site of administration was 20 ml. Intram uscular LS administration, similar to FR, induced short-time (1-1.5 mi nute) psychomotoric uneasiness (3 calves in group 1, 2 calves in group II) without significant influence on the triad value or clinically de tectable reaction of site of administration. Dynamics of the triad val ues in calves of all groups (Tab. I) did not exceed physiological stan dards, including consideration of daily rhythms. Haematological profil e (Figs. 1-4) in evaluated time intervals showed significant differenc es neither in calves of different groups, nor among groups, except leu kocytes whose counts significantly increased six hours after LS admini stration (group 1, p < 0.01) with subsequent decrease on eighth hour o f observation. insignificant changes were also found in evaluation of parameters of acid-base profile, which in groups and among groups with small fluctuations ranged within initial values. The total values of clinical and metabolic reactions of calves to LS administration as eff icient antipyretic in the given therapeutic dose confirmed its good to lerance as well as unburdening effect on studied parameters of interna l medium.