We have critically reviewed the available information on iodine-induce
d hyperthyroidism (IIH) from published sources and other reports as we
ll as the experience of the authors in Tasmania, Zaire, Zimbabwe, and
Brazil. Administration of iodine in almost any chemical form may induc
e an episode of thyrotoxicosis (IIH). This has been observed in epidem
ic incidence in several countries when iodine has been given as prophy
laxis in a variety of vehicles, but the attack rate as recorded has be
en low. IIH is most commonly encountered in older persons with long st
anding nodular goiter and in regions of chronic iodine deficiency, but
instances in the young have been recorded. It customarily occurs afte
r an incremental rise in mean iodine intake in the course of programs
for the prevention of iodine deficiency, or when iodine-containing dru
gs such as radiocontrast media or amiodarone are administered. The bio
logical basis for IIH appears most often to be mutational events in th
yroid cells that lead to autonomy of function. When the mass of cells
with such an event becomes sufficient and iodine supply is increased,
the subject may become thyrotoxic. These changes may occur in localize
d foci within the gland or in the process of nodule formation. IIH may
also occur with an increase in iodine intake in those whose hyperthyr
oidism (Graves' disease) is not expressed because of iodine deficiency
. The risks of IIH are principally to the elderly who may have heart d
isease, and to those who live in regions where there is limited access
to medical care. More information is needed on the long-term health i
mpact of IIH or ''subclinical'' IIH, especially in the course of proph
ylaxis programs with iodized salt or iodinated oil in regions where ac
cess to health care is limited.