The quality of diagnostic ultrasound images is sometimes limited by ex
cessive acoustic attenuation within the organs and tissues. Ultrasound
echo-enhancers help to overcome that limitation by increasing the int
ensity of the reflected signal. Acoustic principles dictate that the m
ost effective enhancers are gas-filled microbubbles. The problem of pr
oducing a microbubble suspension stable enough for routine clinical us
e has been overcome in several ways. Newer developments are leading to
enhancers with an active acoustic response and that have affinities f
or specific organs and tissues. (C) 1997 Elsevier Science Ireland Ltd.