O. Tanaka et al., SINGLE ORAL DOSE KINETICS OF ZOTEPINE AND ITS RELATIONSHIP TO PROLACTIN RESPONSE AND SIDE-EFFECTS, Therapeutic drug monitoring, 20(1), 1998, pp. 117-119
The authors investigated the single oral dose kinetics of zotepine and
its relationship with prolactin response and side effects in 14 healt
hy male volunteers. Each subject took a single oral 25-mg dose of zote
pine, and plasma concentrations of zotepine, prolactin, and their side
effects were monitored up to 36 hours after dosing. The means +/- SD
of the time of maximal plasma concentration (t(max)), the apparent ora
l clearance, the apparent volume of distribution, and the elimination
half-life (t(1/2)) were 3.8 +/- 1.2 hours, 4.6 +/- 4.2 l/h.kg, 109.0 /- 59.0 l/kg, and 21.0 +/- 8.9 hours, respectively. The change in prol
actin concentrations and side effect scores were parallel with that of
drug concentrations, although no significant correlation was found be
tween these three parameters at any time-point. The current results cl
early indicate that the t(max) and t(1/2) of zotepine are much longer
than those previously reported, which are reflected in the changes in
prolactin concentrations and side effect scores.