THE UBIQUITIN-PROTEASOME PATHWAY IN CANCER

Degradation by the 26S proteasome of specific proteins that have been targeted by the ubiquitin pathway is the major intracellular non-lysos omal proteolytic mechanism and is involved in a broad range of process es, such as cell cycle progression, antigen presentation and control o f gene expression. Recent work, reviewed here, has shown that this pat hway is often the target of cancer-related deregulation and can underl ie processes, such as oncogenic transformation, tumour progression, es cape from immune surveillance and drug resistance.