DNA POLYMORPHISM ANALYSIS OF A CASE OF COMPLETE HYDATIDIFORM MOLE COEXISTING WITH A FETUS

A complete hydatidiform mole coexisting with a fetus is a rare conditi on. The diagnosis is often difficult because of the morphological simi larity to a partial mole, but is crucial to management in the postmola r course. We present a case of molar pregnancy coexisting with a fetus in which DNA polymorphism analysis revealed a different genetic origi n for the fetal and molar parts. This is the only known case of a comp lete mole in a twin pregnancy complicated by pre-eclampsia followed by maternal pulmonary oedema. During follow-up, the patient developed a clinically invasive mole which was successfully treated with chemother apy. In this case, genetic analysis unequivocally diagnosed a twin pre gnancy consisting of a complete hydatidiform mole and a fetus.