EFFECTS OF CAMPTOTHECIN, A TOPOISOMERASE-I INHIBITOR, ON PLASMODIUM-FALCIPARUM

Authors
BODLEY AL CUMMING JN SHAPIRO TA
Citation
Al. Bodley et al., EFFECTS OF CAMPTOTHECIN, A TOPOISOMERASE-I INHIBITOR, ON PLASMODIUM-FALCIPARUM, Biochemical pharmacology, 55(5), 1998, pp. 709-711
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Biology
Journal title
Biochemical pharmacology → ACNP
ISSN journal
00062952
Volume
55
Issue
5
Year of publication
1998
Pages
709 - 711
Database
ISI
SICI code
0006-2952(1998)55:5<709:EOCATI>2.0.ZU;2-Z
Abstract
Currently, the treatment of falciparum malaria is seriously compromise d by spreading drug resistance. We studied the effects of camptothecin , a potent and specific topoisomerase I inhibitor, on erythrocytic mal aria parasites in vitro. In Plasmodium falciparum, camptothecin trappe d protein-DNA complexes, inhibited nucleic acid biosynthesis, and was cytotoxic. These results provide proof for the concept that topoisomer ase I is a vulnerable target for new antimalarial drug development. (C ) 1998 Elsevier Science Inc.