SUSCEPTIBILITY OF PSEUDOMONAS-AERUGINOSA TO A PHOTODYNAMIC EFFECT OF THE ARGININE HEMATOPORPHYRIN DERIVATIVE

The photodynamic effect of the arginine hematoporphyrin derivative (Hp D-Arg(2)) on the growth of selected Pseudomonas aeruginosa clinical is olates is described as compared to the effect of hematoporphyrin deriv ative (HpD), Growth inhibition of HpD-Arg(2) of three Gram-positive st rains (Staphylococcus aureus, Bacillus subtilis and Micrococcus luteus ) and five laboratory strains of Cram-negative bacteria (Escherichia c oli, Proteus vulgaris, P. aeruginosa, Klebsiella pneumoniae and Entero bacter cloacae) was observed as well. Serratia marcescens strain was r esistant to light-activated HpD-Arg(2) or HpD. The antimicrobial activ ity of light-activated HpD-Arg(2) against P. aeruginosa may offer an a dditional option in the anti-pseudomonal therapy of wounds. (C) 1997 E lsevier Science B.V.