LONG-TERM EFFECTS OF CCK-AGONIST AND CCK-ANTAGONIST ON FOOD-INTAKE AND BODY-WEIGHT IN ZUCKER LEAN AND OBESE RATS

The present study evaluates long-term effects of the CCK-agonist caeru lein and the CCK-A antagonist loxiglumide in obese and lean Zucker rat s. Caerulein and loxiglumide altered food intake neither in obese nor in lean rats. By as yet unknown mechanisms, however, weight increase w as accelerated by loxiglumide and reduced by caerulein in obese and le an rats. Caerulein increased pancreatic weight only in lean but not in obese rats. Thus, obese rats show a resistance of pancreatic CCK-A re ceptors. The failure of CCK-agonist and -antagonist to alter food inta ke suggests that this CCK-resistance is not responsible for obesity in the genetically altered rats. (C) 1998 Elsevier Science Inc.