INHIBITORY EFFECT OF RADIOSENSITIZER AK-2123 ON EXPERIMENTAL HEPATIC METASTASES AND CA2-TRANSPORT( ACTIVE)

Authors
KONOVALOVA NP VOLKOVA LM TATYANENKO LV KOTELNIKOVA RA YAKUSHCHENKO TN KAGIYA TV
Citation
Np. Konovalova et al., INHIBITORY EFFECT OF RADIOSENSITIZER AK-2123 ON EXPERIMENTAL HEPATIC METASTASES AND CA2-TRANSPORT( ACTIVE), Neoplasma, 44(6), 1997, pp. 361-365
Citations number
27
Journal title
Neoplasma → ACNP
ISSN journal
00282685
Volume
44
Issue
6
Year of publication
1997
Pages
361 - 365
Database
ISI
SICI code
0028-2685(1997)44:6<361:IEORAO>2.0.ZU;2-J
Abstract
A triazole group radiosensitizer AK-2123 is shown to inhibit considera bly the growth of hepatic metastases induced by the intrasplenic injec tion of colon adenocarcinoma cells in syngenic mice. Even an extremely low dose of the drug exhibits the antimetastatic effect. It is shown that AK-2123 injected at therapeutic dose inhibits active transport of calcium ions by the (Ca2+-Mg2+)-dependent ATP-ase. The antimetastatic effect of AK-2123 is suggested to be related, at least partially, to the inhibition of the active calcium transport.