PROLONGED ANURIA COMPLICATING PRIMARY SCLEROSING CHOLANGITIS - SUCCESSFUL OUTCOME FOLLOWING ORTHOTOPIC LIVER-TRANSPLANTATION

A 49-year-old man with progressive obstructive jaundice secondary to p rimary sclerosing cholangitis developed acute, anuric renal failure re quiring prolonged hemodialysis, Renal biopsy showed evidence of tubula r epithelial toxicity, pigmented casts, interstitial fibrosis, and isc hemic glomerular changes, After orthotopic liver transplantation (OLT) , there was an immediate return of urine output. The introduction of t acrolimus (FK506) was delayed for 3 weeks after transplantation, durin g which time a gradual improvement in renal function occurred, Renal f unction remained stable 1 year later at a level of moderate impairment with good hepatic function, (C) 1998 by the National Kidney Foundatio n, Inc.