EVALUATION OF GLUCOSE-TOLERANCE DURING TREATMENT WITH CELIPROLOL IN PATIENTS WITH MILD ARTERIAL-HYPERTENSION WITHOUT DIABETES-MELLITUS

A prospective evaluation of the metabolic effects of Celiprolol, a thi rd generation Beta-Blocking agent was done by 10 general practitioners in 45 mildly hypertensive patients. (diastolic blood pressure greater than or equal to 95 mm/Hg and less than or equal to 115 mm/Hg. In 43 patients with complete data, blood pressure and resting heart rate dec reased significantly after treatment, but weight and metabolic paramet ers were unchanged. After 6 months therapy the 22 patients with an imp aired glucose tolerance test (IGTT) had a significant decrease in plas ma glucose and insulin values, and a tendency for increased HDL. These favorable metabolic effects of Celiprolol in mildly hypertensive pati ents with an abnormal GTT are different from the Findings with other b eta-blockers and justify further study.