CONGENITAL TOXOPLASMOSIS AND SEROCONVERSI ON IN LAST WEEKS OF PREGNANCY - CLINICAL OBSERVATIONS

We report seven cases of subclinical congenital toxoplasmosis secondar y to maternal primary infections. Mothers were infected between two an d four weeks prior to delivery. The diagnostic criteria of congenital infections included :IgM antibody (Ab)(1 case); IgM and IgA Ab (1 case ); a real IgG seroconversion in the neonatal and postnatal samples (3 cases); persistence of IgG Ab beyond 6 months post-delivery (2 cases). A treatment was initiated, including a combination of pyrimethamine+s ulfadiazine (6 cases); trimethoprim+sulfamethoxazole (1 case). This re trospective study suggests that it is important to screen the non-immu ne pregnant women until delivery. We confirmed the usefulness of a com bination of isotypes of antibodies for the accurate assessment of cong enital infection. Finally, infected infants have to be treated and mon itored clinically and immunologically during the first year of life.