PROSPECTS FOR FUTURE STUDIES IN HEAD AND NECK-CANCER

Present therapy of head and neck cancer patients includes surgical pro cedures, radiotherapy and sometimes chemotherapy. Over recent decades no dramatic improvements have been obtained with these treatment modal ities with respect to efficacy and associated morbidity. Of patients w ith early stage disease (stage I and II), about 25% cannot be cured, w hile for patients with advanced disease (stage III and IV) this percen tage may he as high as 70%. However, owing to advances in our knowledg e of molecular biology, immunology, (Mo)chemistry and biology of head and neck squamous cell carcinoma (HNSCC), new perspectives on therapy are arising, After several years of optimization several new therapeut ic approaches are leaving their infancy and are being evaluated in cli nical trials with HNSCC patients, Among other approaches, photodynamic therapy, gene therapy and antibody-based therapy are attracting most attention, The basic concepts and the potential applications of these treatment modalities in the management of head and neck cancer are dis cussed in this paper.