FIXED DRUG ERUPTION DUE TO AMLEXANOX

A 23-year-old woman developed allergic rhinitis in 1993. Her doctor pr escribed for her Solfa (amlexanox 25 mg) and Lysozymen 90 (lysozyme ch loride 90 mg) tablets. She took the tablets occasionally, whenever she developed allergic rhinitis. She noticed a macular erythema of about 3.5 cm wide on her buttocks in 1994, about 1 year after the initial pr escription. We conducted a series of tests with the tablets. On patch testing, the patient had a positive reaction to Solfa 50% pet. on the eruptive area, but no such reaction on the non-eruptive area. Furtherm ore, on patch testing, she had no reaction to Lysozymen 90 50% pet. on either the eruptive or the non-eruptive area. We also used open appli cation test with Solfa 50% pet. to confirm the cause of her erythema.