EVALUATION OF IN-VITRO PRECIPITATION METHODS

Four in vitro precipitation methods were tested and evaluated using fl avopiridol and diazepam formulations. The methods include static seria l dilution, dynamic injection, and dropwise addition with and without stirring. The results generated from these methods are comparable and complementary. The static serial dilution method is most effective in quantifying the amount of precipitation and more descriptive of the fo rmation and redissolution of the precipitate than the others. The dyna mic injection method, however, has its merit in more realistically sim ulating the physiological environment of drug-blood interaction near t he injection sites.