EFFECTS OF CHOLECYSTOKININ TETRAPEPTIDE ON RESPIRATORY-FUNCTION IN HEALTHY-VOLUNTEERS

Objective: The authors evaluated respiratory response to cholecystokin in tetrapeptide (CCK-4) in healthy volunteers. Method: Subjects were r andomly assigned to either a CCK-4 (N=15) or placebo (N=15) challenge under double-blind conditions. Results: Dyspnea was reported by all of the subjects who received CCK-4 but only one subject who received pla cebo. CCK-4 caused a significant increase in tidal volume and minute v entilation br it had no effect on breathing frequency. Placebo had no effect on any of the respiratory measures. Conclusions: These data ind icate that the behavioral effects of CCK-4 are accompanied by changes in respiration in healthy volunteers.