Posthemorrhagic hydrocephalus is a relatively common complication of p
remature birth. One third of patients who do not undergo spontaneous r
esolution require medical management aimed at normalizing intracranial
pressure by correcting the imbalance between cerebrospinal fluid (CSF
) production and drainage. Serial lumbar punctures intermittently remo
ve CSF in bulk. Pharmacologic therapy decreases CSF production. Each o
f these therapies have attendant benefits and risks. For patients whos
e CSF absorption does not improve with growth and recovery, placement
of an indwelling ventricular drain is ultimately required.