Y. Chinen et al., CHARACTERIZATION OF MARKER CHROMOSOMES BY FISH USING MICRODISSECTED PROBES FROM OLD CARNOY-FIXED CELLS - REPORT OF 2 CASES, JPN J HUM G, 42(4), 1997, pp. 543-549
We reported on two patients with a de novo marker chromosome of which
the origins were successfully identified by FISH using microdissected
probes. These probes were established by microdissections of extra chr
omosomal segments from Carnoy-fixed cells stored at -20 degrees C for
several years. Using these probes, we could verify partial 1q32 trisom
y in a patient with 17p+ as well as partial 16q2 trisomy in another pa
tient with 4p+.