CORNEAL ULCER ASSOCIATED WITH DEPOSITS OF NORFLOXACIN

PURPOSE: To report a case of corneal ulcer associated with deposits of norfloxacin. METHOD: Case report. A 40-year old man with right trigem inal and facial nerve palsies and de creased tear secretion developed a corneal ulcer with white deposits in the right eye, The deposits wer e removed and analyzed by high performance liquid chromatography, RESU LTS: High-performance liquid chromatography results disclosed that the deposits on the corneal surface had the same retention time as norflo xacin. The patient discontinued norfloxacin ophthalmic solution and re covered successfully, CONCLUSION: Clinicians should be aware that freq uent applications of topical norfloxacin in patients with decreased te ar secretion may result in deposition of the drug on the cornea.