ANTIBACTERIAL ACTIVITY OF GREPAFLOXACIN

Grepafloxacin has an extremely broad spectrum of activity. Its activit y against Gram-positive bacteria exceeds that of currently available q uinolones. Grepafloxacin-resistant mutants seem to occur less frequent ly than ciprofloxacin-or ofloxacin-resistant mutants, and the increase in MIC against the former mutants is less than that of the latter. Th is applies only to the relative differences (in dilution steps); the a bsolute values are similar. Grepafloxacin kills Gram-positive bacteria at concentrations little above the MIG. Its pharmacodynamic profile a gainst pneumococci is promising, favouring use of this drug for respir atory tract infections.