Ag. Mclennan et al., CHROMOSOMAL LOCALIZATION OF THE HUMAN DIADENOSINE 5',5'''-P-1,P-4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE (AP(4)A HYDROLASE) GENE (APAH1) TO 9P13, Genomics, 47(2), 1998, pp. 307-309
Diadenosine 5',5'''-P-1,P-4-tetraphosphate (Ap(4)A) hydrolase is the e
nzyme responsible for maintaining the intracellular level of the dinuc
leotide Ap(4)A, the function of which has yet to be established. The A
PAH1 gene encoding this Ap(4)A hydrolase has been mapped by fluorescen
ce in situ hybridization and PCR to human chromosome 9p13. Radiation h
ybrid panel mapping further located APAH1 between the IL11RA and the G
ALT genes, thus excluding it as a candidate gene for cartilage-hair hy
poplasia, which maps proximal to GALT. Several tumor suppressor genes
have previously been mapped within the 9p13-p21 region. Given that the
FHIT gene at 3p14.2, which encodes a diadenosine 5',5'''-P-1,P-3-trip
hosphate (Ap(3)A) hydrolase, is a candidate tumor suppressor, APAH1 sh
ould also be considered a potential tumor suppressor. (C) 1998 Academi
c Press.