CANCER RISK AFTER ADJUVANT CHEMOTHERAPY OR CHEMOHORMONAL THERAPY OF BREAST-CANCER

This study is based on 194 patients with primary breast cancer treated with adjuvant CNF combination chemotherapy, who were followed-up for a risk of subsequent neoplasms. During an average follow-up of 4.8 yea rs, 16 cases of new cancers were detected. Nine non-breast cancers wer e observed versus 2.2 expected (standardized incidence ratio 4.2). Of the patients with subsequent malignancies, 88% had received antiestrog en (chemohormonal adjuvant therapy); the percentage among all patients was 25%. We conclude that the benefit derived from adjuvant therapy o f breast cancer may be reduced because of an increased risk of subsequ ent cancers. [(C) 1998 Rapid Science Ltd.].