EXPERIMENTAL PAIN MODELS AND CLINICAL CHRONIC PAIN - IS PLASTICITY ENOUGH TO LINK THEM

Authors
MARCHETTINI P LACERENZA M FORMAGLIO F
Citation
P. Marchettini et al., EXPERIMENTAL PAIN MODELS AND CLINICAL CHRONIC PAIN - IS PLASTICITY ENOUGH TO LINK THEM, Behavioral and brain sciences, 20(3), 1997, pp. 458
Citations number
4
Categorie Soggetti
Psychology, Biological",Neurosciences,"Behavioral Sciences
Journal title
Behavioral and brain sciences → ACNP
ISSN journal
0140525X
Volume
20
Issue
3
Year of publication
1997
Database
ISI
SICI code
0140-525X(1997)20:3<458:EPMACC>2.0.ZU;2-6
Abstract
The central hyperexcitability observed in animal models supports a pat hophysiological explanation for chronic human pain. Novel information on cholecystokinin (CCK) upregulation offers a rationale for reduced o pioid response in neuropathic pain. However, the basic information pro vided by scientists should not lead clinicians to equate experimental models to chronic human conditions. Clinicians should provide careful reports and attempt to classify pathophysiologically clinical conditio ns that have so far been grouped generically.