IN-VITRO EFFECT OF DEXAMETHASONE PHOSPHATE ON HEMATOPOIETIC PROGENITOR CELLS IN PRETERM INFANTS

Authors
PAPOFF P CHRISTENSEN RD HARCUM J LI Y
Citation
P. Papoff et al., IN-VITRO EFFECT OF DEXAMETHASONE PHOSPHATE ON HEMATOPOIETIC PROGENITOR CELLS IN PRETERM INFANTS, Archives of Disease in Childhood, 78(1), 1998, pp. 67-69
Citations number
12
Categorie Soggetti
Pediatrics
Journal title
Archives of Disease in Childhood → ACNP
ISSN journal
00039888
Volume
78
Issue
1
Year of publication
1998
Pages
67 - 69
Database
ISI
SICI code
0003-9888(1998)78:1<67:IEODPO>2.0.ZU;2-2
Abstract
The in vitro effect of dexamethasone on the clonal growth of haematopo ietic progenitors in preterm infants was investigated. Concentrations of 10(6)M to 10(9)M were associated with a dose dependent inhibition o f colony formation, with the most clinically important effects seen on the earliest erythroid and granulocyte-macrophage colonies. Because o f the potential clinical implications of these observations, studies a re needed to determine the effects of dexamethasone an haematopoiesis in preterm infants.