A NEW ROUTE TO ALPHA-FLUOROALKYLPHOSPHONATES

Authors
WASCHBUSCH R CARRAN J SAVIGNAC P
Citation
R. Waschbusch et al., A NEW ROUTE TO ALPHA-FLUOROALKYLPHOSPHONATES, Journal of the Chemical Society. Perkin transactions. I, (8), 1997, pp. 1135-1139
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
8
Year of publication
1997
Pages
1135 - 1139
Database
ISI
SICI code
0300-922X(1997):8<1135:ANRTA>2.0.ZU;2-1
Abstract
Several alkylated alpha-fluorophosphonates have been synthesized by th e reaction of an alkyl iodide, bromide (or activated chloride) with a monofluorosilyllithium phosphonate species produced either from the re action df butyllithium, phenyllithium or other alkyllithium reagent as base and trimethylsilyl chloride with a diethyl monofluoromethylphosp honate. A study of the reaction conditions with respect to the metalla ting agent, silylating agent and-starting monofluorophosphonate has al so been undertaken.