EFFECTS OF NIMODIPINE AND OFLOXACIN ON STAPHYLOCOCCAL BRAIN ABSCESSESIN RATS

The therapeutic effects of nimodipine (GAS 66085-59-4) and ofloxacin ( GAS 82419-36-1) were investigated against experimental brain abscess f ormation in rats. Nimodipine, a 1,4-dihydropyridine derivative, is che mically related to nifedipine but the smooth muscle relaxant effect pr eferentially acts on cerebral arteries. Ofloxacin is a member of 4-Qui nolone broad spectrum antibiotics. Ninety-six male Sprague-Dawley rats were inoculated intracortically with Staphylococcus aureus and then d ifferent groups were treated with either saline. ofloxacin or the comb ination of ofloxacin and nimodipine. The rate of brain abscess formati on and mortality were considerably decreased by nimodipine and ofloxac in therapy. Combination therapy was found histologically to be conside rably more effective than ofloxacin alone against brain abscess format ion in rats.