Ge. Schumacher et Jt. Barr, TOTAL TESTING PROCESS APPLIED TO THERAPEUTIC DRUG-MONITORING - IMPACTON PATIENTS OUTCOMES AND ECONOMICS, Clinical chemistry, 44(2), 1998, pp. 370-374
The Total Testing Process (TTP) refers to the sequence of 11 steps of
laboratory testing, beginning with a clinical question prompted by the
patient-clinician encounter and concluding with the impact of the tes
t result on patient care. TTP when applied to therapeutic drug monitor
ing (TDM) emphasizes that TDM must be considered a process involving a
series of steps and interrelated activities and not viewed simply as
a numerical value for a serum drug concentration. TTP is also an ideal
format for organizing and identifying the system-related and patient-
centered variables used in outcomes assessment of TDM, as well as prov
iding a template for collecting the cost data needed for economic anal
yses. Examples are provided for improving application of TDM by practi
tioners, clinical laboratories, and educators.