THE REACTION OF ORGANOMETALLIC COMPOUNDS WITH THE WEINREB AMIDE OF 3,7-DICHLOROQUINOLINE-8-CARBOXYLIC ACID

Authors
SEONG MR KIM JN KIM HR RYU EK
Citation
Mr. Seong et al., THE REACTION OF ORGANOMETALLIC COMPOUNDS WITH THE WEINREB AMIDE OF 3,7-DICHLOROQUINOLINE-8-CARBOXYLIC ACID, Synthetic communications, 28(1), 1998, pp. 139-145
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
28
Issue
1
Year of publication
1998
Pages
139 - 145
Database
ISI
SICI code
0039-7911(1998)28:1<139:TROOCW>2.0.ZU;2-#
Abstract
The reaction of Grignard or organolithium reagents with the Weinreb am ide of 3,7-dichloroquinoline-8-carboxylic acid afforded 2-substituted derivatives 5 via nucleophilic substitution reaction with hydride tran sfer as the major product instead of the normally expected ketone deri vatives 4.