ONE-ELECTRON REDUCTION OF AROMATIC KETONES BY LOW-VALENT LANTHANIDES - ISOLATION, STRUCTURAL CHARACTERIZATION, AND REACTIVITY OF LANTHANIDEKETYL COMPLEXES

In this paper we report on the isolation, structural characterization, and reactivity of a series of lanthanide ketyl complexes, which are g enerated by reactions of benzophenone and fluorenone with several diff erent types oi lanthanide reducing agents including Ln(OAr)(2)(L)(x) ( Ar = C6H2-Bu-t(2)-2,6-Me-4; 1a: Ln = Sm,L = THF. x = 3; 1b: Ln = Yb, L = THF, x = 3; 1c: Ln = Sm, L = HMPA, x = 2; id: Ln = Yb. L = HMPA, x = 2), (C5Me5)(2)Ln(THF)(2) (La = Sm, Yb), (C5Me5)Sm(OAr)(HMPA)(2), Sm( N(SiMe3)(2))(2)(THF)2, and Ln/HMPA (Ln = Sm, Yb) (HMPA = hexamethylpho sphoric triamide). Reactions of 1a-d with I equiv of fluorenone in THF afforded the corresponding ketyl complexes Ln(OAr)(2)(ketyl)(L)(2) (3 a-d) in 85-90% isolated yields. Hydrolysis of 3a (Ln = Sm, L = THF) ga ve the corresponding pinacol-coupling product, I,2-bis(biphenyl-2,2'-d iyl)ethane-1,2-diol (4), while air oxidation of 3a yielded fluorenone almost quantitatively. Reaction of 3a with 1 equiv of 1a followed by h ydrolysis afforded fluorenol quantitatively. When 3a was dissolved in hexane/ether, pinacol-coupling of the ketyl unit occurred to give the OEt2-coordinated pinacolate complex [Sm(OAr)(2)(OET2)](2)[mu-pinacolat e] 5a, pinacolate = 1,2-bis(biphenyl-2,2'-diyl)ethane-1,2-diolate). Di ssolving Sa in THF regenerated 3a via C-C bond cleavage of the pinacol ate unit, showing that the pinacol-coupling process was reversible, Ad dition of 2 equiv of HMPA (per Sm) to a THF solution of 3a or 5a gave the corresponding HMPA-coordinated ketyl complex 3c, Complex 3c was mo re stable than 3a, and no reaction was observed when 3c was treated si milarly with hexane/ether. Reactions of fluorenone with (C5Me5)(2)Ln(T HF)(2) (Ln = Sm, Yb) and (C5Me5)Sm(OAr)(HMPA)(2) gave the correspondin g ketyl complexes (C5Me5)(2)Ln(ketyl)(THF) (3e: Ln = Sm; 3f: Ln = Yb) and (C5Me5)Sm(OAr)(ketyl)(HMPA) (3i), respectively. In contrast, the s imilar reaction of Sm(N(SiMe3)(2))(2)(THF)(2) with fluorenone in THF y ielded the pinacolate complex [Sm(N(SiM3)(2))(2)(THF)](2)[mu-pinacolat e] (5b) as the only isolable product, although the formation of a kety l species was evident in THF solution, Reaction of 4 equiv of HMPA wit h 5b in THF gave a mixture of Sm(N(SiMe3)(2))(2)(ketyl)(HMPA)(2) (3k) and [Sm(N(SiMe3)(2))(2)(HMPA)](2)[mu-pinacolate] (5c), while reactions of 5b with 4 equiv of ArOH Ar =: C6H2-Bu-t(2)-2,6-Me-4) in TI-IF and THF/HMPA produced the corresponding ArO-ligated ketyl complexes 3a and 3c, respectively. A variable-temperature UV-vis spectroscopic study i n toluene derived a dissociation enthalpy of ii kcal/mol for 5b. React ions of metallic Ln (Ln = Sm, Yb) with 3 equiv of fluorenone and 3 equ iv of HMPA in THF yielded the corresponding tris(ketyl)metal complexes Ln(ketyl)(3)(HMPA)(3) (7a: Ln = Sm, 7b: Ln = Yb). Hydrolysis of 7a,b afforded the pinacol 4, while reaction of 7a with 0.5 equiv of 4 or be nzopinacol produced the fluorenoxide/pinacolate complex 6. Reaction of 4 with Sm(N(SiMe3)(2))(3) in THF/HMPA also afforded 6. In contrast to the reactions of fluorenone, the similar reactions of the above reduc ing agents with benzophenone did not afford a structurally characteriz able ketyl species, and in the case of 1d, the corresponding hydrogen radical abstraction product Yb(OCHPh2)(2)(OAr)(HMPA)(2) (2) was isolat ed.