T4 DNA-LIGASE REDUCES CHROMOSOME-DAMAGE AND ENHANCES CELL-SURVIVAL INCHO CELLS TREATED WITH BLEOMYCIN

Authors
ORTIZ T FLORES MJ PINERO J CORTES F
Citation
T. Ortiz et al., T4 DNA-LIGASE REDUCES CHROMOSOME-DAMAGE AND ENHANCES CELL-SURVIVAL INCHO CELLS TREATED WITH BLEOMYCIN, Cytogenetics and cell genetics, 78(3-4), 1997, pp. 197-201
Citations number
35
Categorie Soggetti
Cell Biology","Genetics & Heredity
Journal title
Cytogenetics and cell genetics → ACNP
ISSN journal
03010171
Volume
78
Issue
3-4
Year of publication
1997
Pages
197 - 201
Database
ISI
SICI code
0301-0171(1997)78:3-4<197:TDRCAE>2.0.ZU;2-H
Abstract
The effect of DNA ligase from T4 phage on the modulation of the damage induced by bleomycin was studied. CHO6 cells were electroporated with either bleomycin alone or bleomycin plus T4 DNA ligase, and both cyto genetic and clonogenic assays were carried out in parallel. Our result s show that T4 DNA ligase is able to decrease the frequency of chromos ome aberrations in bleomycin-treated cells while increasing cell survi val.