ROLE OF DENTINAL CARIOUS LESIONS IN THE PATHOGENESIS OF ORAL CANDIDIASIS IN HIV-INFECTION

The authors describe a clinicopathologic study that evaluated whether dentinal carious lesions are colonized by candidal organisms-and if so , whether there is a relationship between dentinal carious lesion colo nization and clinical oral candidiasis, or OC, in HIV infection. Using light microscopy, the authors examined 30 extracted teeth with dentin al carious lesions from people in each of two groups: 30 consecutively treated HIV-positive patients and 30 consecutively treated HIV-negati ve patients. OC was diagnosed only in HIV-positive patients (40 percen t). The dentinal carious lesion pattern in both groups was similar in occlusal, root and proximal caries. Candidal colonization of carious d entinal tubules was more frequent in HIV-positive subjects than it was in HIV-negative subjects. This research shows that it may be importan t to restore dentinal caries in HIV-infected patients to remove a prot ected niche for candidal organisms.