MANNICH REACTIONS OF RESIN-BOUND SUBSTRATES - 2 - A VERSATILE 3-COMPONENT SOLID-PHASE ORGANIC-SYNTHESIS METHODOLOGY

Authors
MCNALLY JJ YOUNGMAN MA DAX SL
Citation
Jj. Mcnally et al., MANNICH REACTIONS OF RESIN-BOUND SUBSTRATES - 2 - A VERSATILE 3-COMPONENT SOLID-PHASE ORGANIC-SYNTHESIS METHODOLOGY, Tetrahedron letters, 39(9), 1998, pp. 967-970
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
9
Year of publication
1998
Pages
967 - 970
Database
ISI
SICI code
0040-4039(1998)39:9<967:MRORS->2.0.ZU;2-9
Abstract
Alkynes, secondary amines and aldehydes, in the presence of a copper ( I) salt, undergo Mannich reactions to afford the corresponding aminome thylalkynyl adducts on a solid support. Any member of this three-compo nent reaction system can be immobilized on a resin providing three dis tinct routes for the generation of structurally diverse compound libra ries. (C) 1998 Elsevier Science Ltd. All rights reserved.