RAPID AND EFFICIENT SYNTHESIS OF PEPTIDE-FRAGMENTS CONTAINING ALPHA-AMINOISOBUTYRIC-ACID USING FMOC-AMINO ACID CHLORIDES POTASSIUM SALT OF 1-HYDROXYBENZOTRIAZOLE/
Vvs. Babu et Hn. Gopi, RAPID AND EFFICIENT SYNTHESIS OF PEPTIDE-FRAGMENTS CONTAINING ALPHA-AMINOISOBUTYRIC-ACID USING FMOC-AMINO ACID CHLORIDES POTASSIUM SALT OF 1-HYDROXYBENZOTRIAZOLE/, Tetrahedron letters, 39(9), 1998, pp. 1049-1050
The synthesis of peptides containing multiple Aib residues was accompl
ished using Fmoc-Aib-Cl in presence of KOBt. As no additional base was
added, the duration of coupling reactions could be extended. Thus, th
e synthesis of the alamethicin 1-4 fragment, Aib-Pro-Aib-Ala, the emer
imicin 2-6 fragment, Aib-Aib-Aib-Val-Gly and the Aib tetramer, Fmoc-(A
ib)(4)-OBzl were accomplished in good yield and purity. (C) 1998 Elsev
ier Science Ltd. All rights reserved.