LIVER-TRANSPLANTATION IN PATIENTS WITH NON-BILIARY CIRRHOSIS - PROGNOSTIC VALUE OF PREOPERATIVE FACTORS

Background/Aim: The type of disease indicating liver transplantation i s one of the most powerful predictors of postoperative survival. This may be an important problem in evaluating the prognostic significance of other factors when patients with liver diseases of very different n ature are just jointly studied. To minimize this bias, the present stu dy aimed to investigate preoperative prognostic factors in liver trans plantation only in patients with non-biliary cirrhosis. Methods: Twent y-three preoperative standard clinical and laboratory variables were a nalyzed as possible prognostic factors in 162 patients received liver transplantation for non-biliary cirrhosis. Data for seven splanchnic a nd systemic hemodynamic variables were also analyzed in 55 patients. R esults: Using univariate analyses followed by a multivariate analysis, only preoperative blood urea nitrogen (BUN) reached statistical signi ficance as an independent predictor of hospital survival; the survival rate at the end of hospitalization being 90% in patients with BUN les s than or equal to 25 mg/dl and 65% in patients with BUN>25 mg/dl (p=0 .0008). Similarly, preoperative BUN was the only variable independentl y predicting cumulative long-term survival, with an 87% survival proba bility at 1 year and 73% at 4 years in patients with BUN less than or equal to 25 mg/dl, and 61% and 49%, respectively, in patients with BUN >25 mg/dl (p=0.0014). Conclusions: Renal function parameters are the m ost powerful preoperative predictors of survival after liver transplan tation in patients with non-biliary cirrhosis. It is suggested that li ver transplantation is indicated in these patients before marked renal dysfunction develops.