PILOCARPINE SPRAY - AN ALTERNATIVE DELIVERY METHOD

To determine if pilocarpine 4% produces miosis when delivered via a sp ray, eleven eyes of ten patients undergoing a laser peripheral iridoto my for occludable angles were pretreated with one application of piloc arpine spray to closed eyelids. Standardized pupil photographs for pup il diameter measurements were taken before and thirty minutes after th e spray. Contralateral eyes served as controls (9 eyes) All treated ey es achieved miosis. The mean pupil diameter in the treated group was 4 .1 +/- 0.9 mm before the spray and 1.5 +/- 0.3 mm after the spray (p < 0.0001). The average change in pupil diameter in the treated group wa s 2.6 +/- 0.9 mm compared to 0.0 +/- 0.2 mm in the control eyes (p < 0 .0001). Pilocarpine spray is an effective delivery modality for intrao cular miosis.