Aj. Davis et al., LUNG-FUNCTION IN PREMATURE LAMBS AND RABBITS TREATED WITH A RECOMBINANT SP-C SURFACTANT, American journal of respiratory and critical care medicine, 157(2), 1998, pp. 553-559
Citations number
36
Categorie Soggetti
Emergency Medicine & Critical Care","Respiratory System
We evaluated the efficacy of a recombinant surfactant protein-C (rSP-C
) surfactant in vitro and in vivo, using ventilated preterm lambs and
rabbits. The surface tension measured with a Wilhelmy balance of the r
SP-C surfactant was lower than the surface tension of natural sheep su
rfactant (containing SP-B and SP-C). The rSP-C and natural surfactants
were equivalently sensitive to inhibition by plasma. Over a 5-h study
period, lambs treated with 100 mg/kg rSP-C and natural surfactants at
birth had similar Pco(2), lung mechanics, and FRC values. Indicators
of injury also were not different. In preterm rabbits ventilated with
3 cm H2O positive end-expiratory pressure (PEEP), similar compliance r
esponses were measured for the rSP-C and natural surfactant. Large-agg
regate surfactants recovered from alveolar washes of the lambs treated
with rSP-C or natural surfactant retained their function when tested
in preterm rabbits. In conclusion, the rSP-C surfactant was effective
in preterm animals with surfactant deficiency.