PULMONARY INVASIVE ASPERGILLOSIS IN PATIENTS INFECTED WITH THE HUMAN-IMMUNODEFICIENCY-VIRUS - REPORT OF 2 CASES

Patients infected with the human immunodeficiency virus (HIV) have an increased frequency of invasive aspergillosis. We report two cases of invasive pulmonary aspergillosis in patients infected with HIV. Patien ts had less than 10 CD4 (helper cell) cells/mm(3) (2/2), presented wit h fever (2/2), dyspnea (1/2), and abnormal chest radiograph (2/2). Dia gnosis was established by transbronchial biopsy (1/2) and autopsy (1/2 ). Patients died in spite of treatment with intravenous deoxycholate a mphotericin B. Prognosis of invasive pulmonary aspergillosis among pat ients infected with HIV remains dismal, even with aggressive antifunga l treatment.