Purpose: The cause of interstitial cystitis is unknown. We evaluated t
he incidence of Helicobacter pylori antibodies in patients with inters
titial cystitis to determine whether such infection may be a causative
factor. Materials and Methods: We obtained serum samples from 23 pati
ents with interstitial cystitis and 23 control subjects, Samples were
analyzed for the presence of H. pylori IgG antibodies. Results: The in
cidence of positive tests for H. pylori antibodies was 22% in the inte
rstitial cystitis group and 35% in controls. Conclusions: The incidenc
e of infection with H. pylori is not increased in interstitial cystiti
s, and so it is unlikely to be a causative factor.