Purpose: The most devastating complication after the insertion of a pe
nile prosthesis is the development of infection. The standard approach
involves removing the entire device, treating intensively with antibi
otics and attempting to reinsert a prosthesis at a later date, often w
ith a suboptimal result. Based on the encouraging results of others, d
uring the last 24 months we have used in 2 separate private urological
practices a salvage procedure for treatment of infected inflatable pe
nile prostheses. Materials and Methods: The protocol used in 7 men wit
h an infected inflatable penile prosthesis included removal of all dev
ice components, a 7-step vigorous intraoperative irrigation with 4 dif
ferent solutions, including vancomycin, immediate reimplantation of a
new inflatable penile prosthesis and postoperative outpatient antibiot
ics with oral ciprofloxacin or intravenous vancomycin or cefazolin. Re
sults: Of the 7 men 6 have experienced excellent results with no infec
tion, minimal morbidity and preservation of penile length. The only fa
ilure occurred in a poorly controlled diabetic who required multiple r
evisions and may have had latent infection for months before it became
apparent. Conclusions: We believe that an immediate salvage procedure
for an infected inflatable penile prosthesis is an effective treatmen
t for this difficult complication.