R. Fornasier et al., MODERATE ENANTIOSELECTIVITY PROMOTED BY CYCLODEXTRINS IN THE ZN-BARBIER ALLYLATION REACTION OF ALDEHYDES IN AQUEOUS-MEDIUM, Silicon, germanium, tin and lead compounds, 21(1), 1998, pp. 65-67
The effects exerted by native and trimethylated (-cyclodextrins in the
Zn-Barbier allylation reaction of aldehydes in aqueous solution has b
een studied. The rates of conversion were, generally, depressed in the
presence of the cyclodextrins, especially TMCD, but the chemical yiel
ds of the products were very satisfactory, in all cases. Moderate enan
tioselectivity effects were also obtained in the presence of TMCD, whe
reas native (CD showed to be practically inactive. The results can be
rationalised in terms of formation of inclusion complexes between the
substrates and the CDs and of their interaction with the surface of th
e metal.