Re. Warwar et al., CYSTOID MACULAR EDEMA AND ANTERIOR UVEITIS ASSOCIATED WITH LATANOPROST USE - EXPERIENCE AND INCIDENCE IN A RETROSPECTIVE REVIEW OF 94 PATIENTS, Ophthalmology, 105(2), 1998, pp. 263-268
Objective: This study aimed to investigate the incidence of cystoid ma
cular edema and anterior uveitis associated: with the use of latanopro
st. Design: A retrospective review of patients treated with latanopros
t in the authors' practice between September 1, 1996, and August 1, 19
97, was performed. Participants: Ninety-four patients and 163 eyes wer
e studied. Intervention: Patients presenting with signs and symptoms o
f ocular inflammation while receiving latanoprost were noted, and thei
r response to the discontinuation of the drug was recorded. Main Outco
me Measures: The presence and degree of anterior uveitis and cystoid m
acular edema were measured. Results: Six (6.4%) of 94 patients (8 [4.9
%] of 163 eyes) had anterior uveitis develop, and 2 (2.1%) of 94 patie
nts (2 [1.2%] of 163 eyes) had cystoid macular edema develop while bei
ng treated with latanoprost. Conclusion: Although latanoprost is an ef
fective ocular-hypotensive agent, the authors' experience with the dru
g has shown a significant incidence of anterior uveitis and cystoid ma
cular edema. To the authors' knowledge, this is the first study to rep
ort the incidence of both cystoid macular edema and anterior uveitis a
ssociated with latanoprost therapy, Treating physicians should be awar
e of these potential complicating side effects of latanoprost.