VASCULAR TYPE-I AND TYPE-II TRANSFORMING-GROWTH-FACTOR-BETA RECEPTOR EXPRESSION - DIFFERENTIAL DEPENDENCY ON TYROSINE KINASES DURING INDUCTION BY TGF-BETA

Authors
WARD MR AGROTIS A JENNINGS G BOBIK A
Citation
Mr. Ward et al., VASCULAR TYPE-I AND TYPE-II TRANSFORMING-GROWTH-FACTOR-BETA RECEPTOR EXPRESSION - DIFFERENTIAL DEPENDENCY ON TYROSINE KINASES DURING INDUCTION BY TGF-BETA, FEBS letters, 422(2), 1998, pp. 197-200
Citations number
29
Categorie Soggetti
Biology,"Cell Biology",Biophysics
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
422
Issue
2
Year of publication
1998
Pages
197 - 200
Database
ISI
SICI code
0014-5793(1998)422:2<197:VTATTR>2.0.ZU;2-2
Abstract
Recent evidence indicates that the type II transforming growth factor- beta (TGF-beta) receptor (T beta RII) is a serine-threonine-tyrosine k inase. However, the significance of its tyrosine kinase is unclear. We investigated in vascular smooth muscle cells the effects of tyrosine kinase inhibition on the expression of TGF-beta receptor types I (ALK- 5) and II (T beta RII) mRNA, induced by TGF-beta(1). TGF-beta(1) eleva ted ALK-5 mRNA levels 5-fold; essentially similar TGF-beta(1)-dependen t elevations were observed,vith growth factors, PDGF-BB and FGF-2. The tyrosine kinase inhibitor genistein abolished these TGF-beta(1) and g rowth factor responses. TGF-beta(1) also elevated T beta RII mRNA leve ls which were not inhibited by genistein. We conclude that tyrosine ki nases participate in defining how cells respond to TGF-beta. (C) 1998 Federation of European Biochemical Societies.